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Glossary · updated May 2, 2026

Pre-Employment Drug Test

By Korey Sharp-Paar · Reviewed by the Fast Trucking Compliance team

Definition

A pre-employment drug test is a controlled-substance test the motor carrier must administer to every CDL applicant before allowing the driver to perform safety-sensitive functions, under 49 CFR §382.301. The test must screen for marijuana, cocaine, opiates, phencyclidine, and amphetamines (including methamphetamine and MDMA) using a 5-panel urine specimen. The carrier must also run a Clearinghouse full query under §382.701(a) before the first dispatch. A negative result must be received before the driver can be released for over-the-road duty; positive results, refusals, or substituted specimens move the driver into Clearinghouse "prohibited" status.

Authoritative source

49 CFR Part 382 - Controlled substances and alcohol

Read more

Drug & Alcohol Consortium Guide

Why owner-operators must enroll, random testing rates, and Clearinghouse reporting.

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